Abstract
Magnesium citrate solution prepared in the hospital by the recipe of National Formulary XIV (N. F. XIV) is apt to generate precipitation and is not stable. It is examined Whether the solution is tabiiized by adding pH 4.1 Sorenson Buffer Sol.(C.Buffer) C. Buffer was added to the test fiuids at a regular interval to make 10 of 2, 4, 6, 8, 10, 20% specimen. Then they were sterilized under 3 different conditions and preserved at 3 different temperatures of 4°, 25°and 46°.
They were observed macroscopically and stability days were recorded. As a result, among those specimens of over 10% addition, only specimen steriiized at 100° for 1 hour or those preserved at 4° and 25° after steriiization at 115°for 30 minutes and those preserved at 25° aftersterilizationat1210for 20mimteswerestableformorethan6months.From this data it is found that the addition of C. Buffer is effective to stabilize magnesiunm citrate solution. Further, from the study of solution whose sterilization conditions have, not been mentioned precisely in N. F.XIV, it can be concluded that sterilization at 115° for 30 minutes is recommended and the optimum temperature for storage is 25°.
