Release and Rectal Absorption of Phenytoin Suppositories

Abstract

Lyophilized phenytoin was mixed with Witepsol H-15, S-55 and glycerogelatin to manufacture suppositories, and physical properties as well as release and rectal absorption in rabbits were studied. Phenytoin suppositories mixed with Witepsol H-15 and glycerogelatin showed a similar release action, while not a significant difference was observed in C (max) and A. U. C. Phenytoin suppositories combined with Witepsol S-55 showed a significant difference in a release action, C (max) and A. U. C. from other suppositories. Not asignificant difference in blood concentration was shown between the suppository and oral administration except the level after use of Witepsol S-55.