Abstract
The quality of five brands (A to E) of sugar-coated tablets containing 5 or 10 mg of medazepam was studied in terms of pharmaceutical properties. Although all the products tested met the requirements for the disintegration test according to J.P. IX, the disintegration time of Product D was 3 to 4 times longer than those of the other products. In the dissolution test, the results obtained by the rotating basket method were similar to those by the paddle method. A good correlation was noted between the dissolution rate and the disintegration time. The dissolution rates of four brands reached about 100% within 30 minutes, except the rate of Product D which was only 7% even after 60 minutes, possibly due to obstruction of the dissolution by the layer of sugar coating.
