Abstract
Brompton mixture was used for reducing the pain in cancer patients at the terminal stage. The mixture was effective in treatment and caused no adverse reactions, such as cloudiness of consciousness, personality deviation, and psychological dependency and tolerance. Some patients were able to take the mixture orally until the day just before death. The effectiveness of the Brompton mixture was investigated on 34 patients. It was considered that the increase in dose to reduce a pain might be due to the increase of pain associated with exacerbation of cancer and/ or malabsorption of morphine rather than drug tolerance to morphine. Morphine concentration in plasma of a patient with pain well-controlled by the mixture was about 0.4μg/ml. Adverse reactions of the Brompton mixture were decreased in parallel with the use of prochlorperazine and other drugs.
