Abstract
The quality of two kinds of commercial pindolol tablets, uncoated A and sugar-coated B, was evaluated by 3 tests: dissolution, weight variation, and content uniformity. The dissolution test was made with Sartorius Solubility Simulator. The weight variation test was made according to the method prescribed in J. P. X. In the content uniformity test, both tablets A and B were dissolved in 0.1 N HCL solution. Pindolol was determined spectrophotometrically.
Following results were obtained: 1) In the dissolution test, 50% dissolution time of the two kinds of tablets was almost the same. However, the dissolution ratio at 5 min of the tablet A was significantly higher than that of the tablet B. 2) In the weight variation test, the tablet A met the criteria of J. P. X, and the weight variation of the tablet B was also very small. 3) In the content uniformity test, the mean contents of the two tablets were about 100%.
