Japanese Journal of Hospital Pharmacy
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
Stability and Decomposition Substances of Ubidecarenone Granules and Fine Granules on Exposure to Light
MINORU HIRAHARAMASAFUMI OGAWAMAKOTO SHIGEMATSUKATSUYA NAGAYAMAATSUKO SATAKEKOJI HORIITSUMI MIYABE
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1983 Volume 9 Issue 5 Pages 384-388

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Abstract
A high performance liquid chromatograph (HPLC) was used for the quality test of Ubidecarenone (CoQ10) products. CoQ10 products were exposed to light under 2000 lux for 29 days, and their stability to light was studied with HPLC.
The results were as follows: 1) Good separation of CoQ10. CoQ9 and UC9 was achieved with HPLC. 2) The amount of CoQ10 in granules and fine granules packed with Pile Packer Film was between 11% and 18% after 29-day exposure to light, whereas CoQ10 in granules in lightshielded package and that in raw material powder packed with pile packer Film were 74% and 90%, respectively. 3) The main decomposition substance of the granules, the fine granules and raw material powder showed that the relative retention to CoQ10 was 0.49.
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© Japanese Society of Pharmaceutical Health Care and Sciences
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