Stability and Releasability of Adriamycin Ointment

Abstract

The stability of adriamycin in macrogol ointment and hydrophilic ointment was studied for 4 weeks at room temperature and 5° by the bioassay and HPLC methods. Both preparations remained sufficiently stable through the 4 weeks after formulation. The releasability of adriamycin from these 2 ointment preparations was confirmed by using the diffusion tests of adriamycin based on chromatography and agar-agar methods. The results suggest that the diffusion of adriamycin may depend on the ointment base.