Method of Dissolution Test for a Practically Insoluble Drug, Glibenclamide

Abstract

A dissolution test for practically insoluble drugs was developed and applied to 4 preparations of glibenclamide. The results showed that with this method it has become possible to evaluate the difference of dissolution rate of the preparations with good reproducibility for dissolution profile. Two preparations of glibenclamide made by 1 manufacturer indicated that their dissolution rates were much lower than those of 2 preparations made by the other.