Fungistatic Action of the Total Parenteral Nutrition (TPN) Fluids Against Clinically Isolated Candida abicans

Abstract

In order to examine the fungistatic action of TPN fluids against Candida abicans, which was clinically isolated and chosen as a model fungus because of its high risk of infection, we attempted to compare the TPN products commonly used at our hospital. Furthermore, we also investigated the effects of pH and sodium bisulfite (NaHSO₃) on this action. Under the respective conditions of a lower pH or higher concentration of NaHSO₃, the fungistatic action was weakly recognized, however, under the both conditions (lower pH and higher concentration of NaHSO₃), a remarkable fungistatic action was observed.