Treatment of Peptic Ulcers in order to Eradicate Helicobacter Pylori by the Administration of Rabeprazole with Two Antibiotic Drugs for a Two week Period

Abstract

Triple therapy (proton pump inhibitor + amoxicilln + clarithromycin) for one week is considered to be thecommon eradication therapy for Helicobacter pylori (H. pylori) infection.
The H. pylori eradication rate has been reported to be 87. 5% after the administration of sodium rabeprazole, which is a proton pump inhibitor, along with two antibiotic drugs for one week [H. Miwa et al., Aliment. Pharmacol. Ther., 13, 741-746 (1999)] We performed a retrospective study to evaluate the treatment of 42 patients with H. pylori infection by the administration of sodium rabeprazole with two antibiotic drugs for a twoweek period. As a result, the H. pylori eradication rate was 93 % (39 of 42 patients). A successful healing of thepeptic ulcer with H. pylon was observed in all 39 patients. Side effects such as mild diarrhea appeared in onlyone patient. The triple therapy with sodium rabeprazole, amoxycillin, and clarithromycin for two weeks wastherefore found to be sufficiently effective in healing peptic ulcers with an H. pylori infection.