Abstract
The sensitivity of 16 species of bacteria (68 strains) isolated from clinical materials to Acrinol was investigated from 2000 to 2001. Acrinol was effective against Staphylococcus aureus and other gram-positive cocci. The minimum inhibitory concentration (MIC) of Acrinol for S. aureus including MRSA ranged from 100 to 200 μg/mL. However, Acrinol was less effective against gram-negative rods than for gram-positive cocci. The MIC of Acrinol for Eschericia coli was 200-800 μg/ mL, and it was over 1, 600 μg/mL for Proteus vulgaris and Proteus mirabilis. On the other hand, Acrinol was effective against the multiple drugresistant Pseudomonas aeruginosa, and the MIC of Acrinol for all strains of P. aeruginosa (including some resistant to almost all antibiotics) ranged from 200-1, 600 μg/mL, the commonly used concentration range of Acrinol. When exposed to light of 500 lx for 90 days, Acrinol changed color but its antibacterial activity was maintained. These results suggest that Acrinol is a useful drug for the treatment of infected skin lesions.
