Decreased Exhaled Nitric Oxide in Mild Persistent Asthma Patients Treated with a Leukotriene Receptor Antagonist, Pranlukast

Hirosuke Kobayashi; Yuko Takahashi; Hisashi Mitsufuji; Ryuji Hataishi; Tailin Cui; Naohiko Tanaka; Tadashi Kawakami; Tomoyuki Tomita

doi:10.2170/jjphysiol.49.541

Short Communications

Decreased Exhaled Nitric Oxide in Mild Persistent Asthma Patients Treated with a Leukotriene Receptor Antagonist, Pranlukast

Hirosuke Kobayashi, Yuko Takahashi, Hisashi Mitsufuji, Ryuji Hataishi, Tailin Cui, Naohiko Tanaka, Tadashi Kawakami, Tomoyuki Tomita

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Keywords: nitric oxide, bronchial asthma, leukotrienes

JOURNAL FREE ACCESS

1999 Volume 49 Issue 6 Pages 541-544

DOI https://doi.org/10.2170/jjphysiol.49.541

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Abstract

Exhaled nitric oxide (NO) level decreases after corticosteroid treatment in asthmatics, but the effect of a leukotriene receptor antagonist, pranlukast, on exhaled NO has not been elucidated. Pranlukast treatment in mild persistent asthmatics for 4 weeks decreased the exhaled NO level, which did not differ from the levels in healthy subjects.

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