The Japanese Journal of Physiology
Print ISSN : 0021-521X
Short Communications
Upregulation of P53 Protein in Rat Heart Subjected to a Transient Occlusion of the Coronary Artery Followed by Reperfusion
Zhonglin XieTomiyasu KoyamaKazuhiro AbeYukiko FujiiHirofumi SawaKazuo Nagashima
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2000 Volume 50 Issue 1 Pages 159-162

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Abstract
The accumulation of p53 protein in cardiomyocyte nuclei was immunohistochemically demonstrated by the pronounced staining of p53 antibody in 4 h–reperfused ventricular tissue after a 45-min coronary occlusion. The occurrence of apoptosis in the reperfused ventricular tissue was evidenced by positive TUNEL staining and DNA laddering on agarose gels.
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© 2000 by The Physiological Society of Japan
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