Abstract
Although the elevation of angiotensin II (Ang II) associated with cardiovascular diseases has been considered to suppress the arterial baroreflex function, how Ang II affects dynamic arterial pressure (AP) regulation remains unknown. The aim of the present study was to elucidate the acute effects of Ang II on dynamic AP regulation by the arterial baroreflex. In seven anesthetized Japanese white rabbits, we randomly perturbed intra-carotid sinus pressure (CSP) according to a binary white noise sequence while recording renal sympathetic nerve activity (RSNA) and AP. We estimated the neural arc transfer function from CSP to RSNA and the peripheral arc transfer function from RSNA to AP before and after 30-min intravenous administration of Ang II (100 ng/kg/min). Ang II increased mean AP from 75.7 ± 3.1 to 95.5 ± 5.1 mmHg (p < 0.01), while it did not affect mean RSNA (from 5.9 ± 1.3 to 5.7 ± 1.2 a.u.). The neural arc transfer functions did not differ before or after Ang II administration (dynamic gain: −0.94 ± 0.04 vs. −0.94 ± 0.13, corner frequency: 0.06 ± 0.01 vs .0.06 ± 0.01 Hz, pure delay: 0.16 ± 0.01 vs. 0.17 ± 0.02 s). The peripheral arc transfer function did not differ before or after Ang II administration (dynamic gain: 1.18 ± 0.05 vs. 1.06 ± 0.11, natural frequency: 0.07 ± 0.01 vs. 0.08 ± 0.01 Hz, damping ratio: 1.19 ± 0.06 vs. 1.24 ± 0.19, pure delay: 0.83 ± 0.06 vs. 0.78 ± 0.05 s). Intravenous Ang II hardly affects the dynamic characteristics of neural and peripheral arc around the physiological operating pressure.
