Does Higher Red Blood Cell (RBC) Lactate Transporter Activity Explain Impaired RBC Deformability in Sickle Cell Trait?

Philippe Connes; Fagnété Sara; Marie-Dominique Hardy-Dessources; Maryse Etienne-Julan; Olivier Hue

doi:10.2170/jjphysiol.S653

Philippe Connes, Fagnété Sara, Marie-Dominique Hardy-Dessources, Maryse Etienne-Julan, Olivier Hue

Author information

Keywords: hemorheology, sickle cell trait, lactate

JOURNAL FREE ACCESS Advance online publication

Article ID: 0601300020

DOI https://doi.org/10.2170/jjphysiol.S653

The final version of this article is now available: Vol. 55 (2005) , No. 6 p.385

Details

Abstract

Lactate and H⁺ are suggested to promote sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers.

Corresponding author

Register with J-STAGE for free!