Abstract
1. Chronic treatments with Pitressin produced increases in RNA-P and total nitrogen contents in livers of normal rats, while DNA-P content remained unchanged. Pitocin had no effect.
2. After hypophysectomy RNA-P and total nitrogen contents in liver reduced considerably; administration of growth hormone restored the decreased contents toward normal level, while Pitressin was ineffective.
3. Chronic treatments with Pitressin induced a significant enlargement of epiphyseal cartilage width of tibia in normal rats. Pitocin had no effect.
4. In hypophysectomized rats the width was markedly reduced; growth hormone, but not Pitressin, restored the narrowed width toward normal.
5. Administration of cortisone acetate produced a marked gain in liver weight and a slight increase in RNA-P content.
