Abstract
Sleep states and their induction by sodium butyrate were studied in acute “encéphale isolé”(transection at the spinal cord C1 level) and “IMPM”(“isolated midbrain-pons-medulla”)(precollicular decerebration and transection at the spinal cord C1 level) preparations. The naturally occurring ortho- and para-sleep states were observed in the “encéphale isolé” preparation. The intravenous administration of sodium butyrate (1.5-2 mM/kg) induced orthosleep state of 2- to 6-min duration, followed by a 2-12 min period of the parasleep state. Similarly, in the “IMPM” preparation para-sleep state was observed, and also was induced by the butyrate. When the same amount of the butyrate (1.5 mM/kg) was given repeatedly at about 1 hour intervals, para-sleep state was reproducible in these preparations.
