Abstract
Effects of denervation, reserpine syrosingopine, lidocain, antihistamine, acetylcholine and atropine were investigated in order to evaluate these factors in the cold-induced increase of blood flow through interscapular brown adipose tissue in the rat.
Denervation of brown fat immediately before acute cold exposure did not. prevent the increase in blood flow in brown fat induced by cold exposure. Denervated fat pad 8 days of ter the operation also responded well to cold exposure with an increase in blood flow. However, the blood flow in the denervated pad was significantly less than in the intact one when exposed to cold.
Topical application of lidocain around brown fat and subcutaneous administration of reserpine effectively blocked the blood flow increase in response to cold exposure. Reserpine treated animals exhibited a decreased cardiac output and blood flow in epididymal fat when exposed to cold.
Syrosingopine, dextrochlorpheniramine, and atropine did not prevent the cold-induced increase in the blood flow in brown fat.
Acetylcholine infusion caused a significant increase in the cardiac output and blood flow in brown fat, but not in epididymal white fat.
