Abstract
Transmembrane potentials of the ventricle of the isolated chicken embryo heart were recorded by a microelectrode technique. Substitution of foreign anions for chloride depressed the aconitine-induced rapid firing of the specimens. The effectiveness of anions in depressing the rapid firing was in the order of thiocyanate, iodide, nitrate, bromide, and then acetate. Alteration in chloride permeability participates in the process of the arrhythmias, and foreign anions can affect the arrhythmias.
