Abstract
Effect of tetrodotoxin (TTX) on the aconitine-induced arrhythmias of the isolated cardiac tissues of the chicken embryo, the toad and the golden carp is studied by a microelectrode technique. TTX in a dose of 10-8-10-7g/ml antagonized the aconitine-induced rapid firing in the chicken embryo ventricle, the toad atrium and the golden carp atrium. TTX was much more potent than lidocaine in exerting an antiarrhythmic effect. The mode of action of aconitine and TTX is discussed.
