LATS-INDUCED STIMULATION OF THYROIDAL GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN THE MOUSE

Abstract

Effect of LATS or TSH on the G-6-PDH activity in mice thyroid was studied. By a single injection of TSH or LATS the increase of enzyme activity did not occur promptly. By the 10 days' injection of LATS or TSH, the enzyme activity increased significantly, being accompanied with the increase of thyroid weight. The augmentation rate of the enzyme activity in mice thyroid and of the thyroid weight were accelerated when LATS or TSH was injected for 10 days. These results suggest that LATS increases G-6-PDH in the thyroid similar to TSH.