Abstract
In order to elucidate the central action mechanism of choiecystokinin (CCK), effects of this peptide on norepinephrine, dopamine and serotonin contents in the brain were observed in saline control, α-methyl-p-tyrosine-, L-DOPA- and pargyline-pretreated rats.Intraperitoneal injection of CCK in a dose of 40U/kg did not produce any significant changes in the monoamine contents.However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.
