Effect of Cobalt on Electrical and Mechanical Responses to Exogenous Noradrenaline and to Field Stimulations in the Guinea-pig Vas Deferens

Abstract

Co²⁺ suppressed the mechanical responses evoked by field stimulations and by application of noradrenaline (NA) in the smooth muscle of guinea-pig vas deferens. However, the membrane excitation and force development evoked by depolarizing currents were not much affected in the Co²⁺ treatment. It is proposed that Co²⁺ suppresses NA induced contraction by inhibiting the development of the membrane depolarization.