Abstract
1. Analbuminemic rats died within 18h after a rapid decrease of body temperature whereas control Charles River, Wistar, and Sprague Dawley rats survived for 40h, when the animals were kept at 5°C without food. 2. Five low molecular weight fractions obtained from Sprague Dawley rat sera were administered to analbuminemic rats kept under these conditions. The duration of survival was extended by the administration of two of the fractions. 3. Several characteristics of one of these fractions coincided with those of uric acid, and body temperature of analbuminemic and Sprague Dawley rats increased within 5min after uric acid administration.
