INFLUENCE OF ANTIDIURETIC HORMONE ON ADRENAL CORTICAL ACTIVITY IN RATS

Abstract

Adrenal cortical activity were studied by the determination of ascorbic acid content of adrenals in rats.
1. The adrenal ascorbic acid content in rats which had been deprived of water for 48 hours, increased to slightly above normal content. Similar results were obtained in the pituitrin administered animals.
2. The adrenal ascorbic acid content of rats after massive intraperitoneal injection of 5 per cent glucose showed a nearly normal value.
3. Marked depletion of adrenal ascorbic acid was observed in rats after administration of epinephrine or stress, but it was not so significant in animals which had been injected with pituitrin or dehydrated.
4. In rats after heavy water load, the excretion of water was rapid and adrenal ascorbic acid content decreased remarkably, compared with animals administered intraperitoneally with the same amount of water.
5. Administration of large doses of pituitrin depleted the adrenal ascorbic acid content.