ON THE RÔLE OF THE PUPILLO-CONSTRICTORY CENTERS IN THE ADRENALINMYDRIASIS AND-MIOSIS

Abstract

In decerebrate and non-decerebrate cats the impulses from the short ciliary nerve were recorded. From the changes of the impulse frequency following the intravenous injection of adrenalin, the rôle of the pupillo-constrictory centers on the adrenalin-mydriasis and-miosis was studied.
1) In non-decerebrate cats the impulses from the short ciliary nerve were inhibited for several minutes by adrenalin.
2) In decerebrate cats the effect of adrenalin was reversed to excitatory effect.
3) In the cats administered chlorpromazine a similar excitatory effect to that in decerebrate cats was elicited by adrenalin.
4) From these results the mechanism of the action of adrenalin upon the pupillo-constrictory centers was discussod.
5) In decerebrate cats with no blood stream of the eye, the pupil was constricted by i.v. injection of adrenalin. This is a miosis of the central origin.