Clinical Observations of the Treatment of Non-Specific Complaints Caused by Ovarian Dysfunction

Abstract

It this paper, the author investigated the relationship between the ovarian function and non-specific complaints following vitamin E administration in 7 female patients whose ages ranged from 19 to 46. Their non-specific complaints had developed in relatino to adolescence, post delivery, post artificial abortion or climacteric period. At the beginning of treatment, the patients showed different patterns of basal body temperature courve such as seen in non-ovulation, impairment of luteal phase (severe, slight), impairment of follicular phase (variant type or high temperature phase of follicular phase), and imbalance of the period of follicular and luteal phase (follicular phase>luteal phase, follicular phase<luteal phase).For the purpose of improving ovarian dysfunction observed in those patients, a single administration of vitamin E (α-tocopherol acetate, 300mg per day orally) or a combined administration of vitamin E and chlordiazepoxide (20mg per day orally) was carried out in all patients. After 3 to 4 months of this treatment, initial non-specific complaints more or less disappeared concomitantly with the improvement of basal body temperature curve in all patients. Four out of 7 patients showed various periodical complaints such as nausea, stomach distress, stomachache, sore neck, stiff shoulder or headache in the follicular or ovulation phase in which the abnormal pattern of basal body temperature curve appeared. However, these complaints also disappeared in all patients after the normalization of basal body temperature curve.The above-mentioned facts seem to suggest that the control of ovarian function plays an important role in the treatment of non-specific complaints which were developed due to the changes in endocrinological environment of female gonadal glands.