Abstract
This report is concerned with 2 girls, 10 and 11 rears old, of a same family who were almost simultaneously performed amputation and chemothrerapy for osteosarcoma. The younger sister complained of severe phantom limb pain and nausea and vomiting which occur at any time prior to chemotherapy injection, whereas the older sister did not complained of her symptoms in the postoperative course. Their family life history revealed that both of their parents were psychologically inmature and showed instability and tension. Psychological tests indicated that the younger sister suffered severe anxiety and was frustrated by chemothrapy and leg amputation. The parents' psychological instability might have influenced her. Her severe pain and frequent nausea were relieved by ralaxation training. On the other hand, the older sister frankly expressed her psychological distress and easily received chemotherapy due to the short period of its course without nausea and vomiting. Differential clinical pictures of the two sisters were discussed from the paychosomatic view point.
