Abstract
Deep involvement of the psychological stress is found in the relapse or recrudencene of gastroduodenal ulcer indeed, but no objective index thereof has been available yet. On 22 cases of gastroduodenal ulcer which showed relapse or recrudescene during observation and which were taken from among periodically followed-up patients with gastroduodenal ulcer, we recently determined so-called "stress markers (serum indicators of stress)" such as cortisol, free fatty acid, uric acid before and after relapse or recrudescene of ulcer and examined comparatively pre- and post-values, together with serum gastrin and MAS. After the relapse or recrudescence, all of cortisol, free fatty acid, uric acid, gastrin, and MAS values tended to be higher, and especially free fatty acid showed significant higher post-values when relapsed or recrudescened ulcer was still in the active stage and cortisol in the case of duodenal ulcer. These findings suggest positive involvement, at blood level, of the psychological stress in the relapse or recrudescene of ulcer.
