Abstract
We have previously reported that increase of bronchial responsivenes in the restriction stress guinea pig group as compared to that in controls was observed. Moreover, radical oxygen products from bronchoalveolar lavage fluid (BALF) cells obtained from the stress group were also increased, suggensting these phenomena might accelerate the phenomena of inflammatory reactions. On the other hand, adhesion molecules, especially intercellular adhesion molecule-1(ICAM-1), are considered to play an important role in inflammatory processes in allergic and immune reactions such as bronchial asthma. Therefore, in this study, our investigation was designed to clarify whether stress is involved in adhesion molecules expression on inflammatory cells and endothelial cells (EC). Results were as follows ; 1) IL-1,which is considered to play an important role in psychoneuroimmunological phenomena, induced ICAM-1 expression on human EC. 2) Moreover, PAF and PF4,which may be stricking chemotactic agents and activating agents for eosinophils, also induced ICAM-1 expression on human EC. 3) The leukocyte adherence to plasma coated glass in the electric shock stress guinea pig model was augmented as compared to that of controls. 4) Eosinophil counts as well as eosinophil percentages in adherent leukocytes in the electric shock stress group were greater than those of controls. 5) Moreover, leukocyte adherence to autologous bronchial ciliary cells was also augmented in the stress group as compared to that of controls. In conclusion taken together, stress might be involved in adhesion molecules expression resulting in acceleration of allerginc inflammatory reactions such as bronchial asthma.
