The Psychiatric Bias in Functional Dyspepsia: : The Prevalance and the Relation to the Symptoms Severity and the Gastric Function(Symposium/Brain-gut Interaction in the Pathophysiology of Functional Dyspepsia)

Abstract

Underlying causes of symptoms in functional dyspepsia (FD) are multi-factorial, including delayed gastric emptying, impaired gastric accommodation, visceral hypersensitivity and psychiatric distress (PD). However, the impact of these abnormal gastric physiology and psychiatric distress on the severity of daily dyspeptic symptoms (DS), and the correlation among these causes are still unclear. We studied the impact of abnormal gastric physiology and psychiatric distress on the severity of daily DS, and to examine the correlation among these multi-factorial causes in FD. Thirty-three FD (Rome II) patients were evaluated by gastric emptying study (GES), and water load drink test (DT). Subjects also completed STAI, SDS, CMI and the original dyspeptic symptoms questionnaire to examine DS severity (strength and frequency). The correlation between DS severity with GES, DT, and PD were examined. The correlation among GES, DT, and PD were also examined. In FD, both DT and PD correlated significantly with DS severity, and significant correlation was noted between DT and PD. In FD, both intolerance to volume load in DT and PD enhanced DS severity, and PD may influence the gastric physiology assessed by DT.