Long-term Administration of SSRI in PADAM Outpatient

Abstract

The diagnosis or the treatment of PADAM (partial androgen deficiency in aging men) has not been established yet. PADAM patients often complicate mood or anxiety disorders. The objective of this study was to evaluate the long-term effect of long-term paroxetine to mood or anxiety disorder complicated with PADAM. One hundred and eight male patients who had visited to our outpatient department of PADAM and had been treated with paroxetine were investigated. Patients were divided three groups by paroxetine treatment condition; short-term treatment group (<1 year, n=37), long-term treatment group (≧1 year, n=18) and continuing treatment group (n=36) . The SDS score before treatment by paroxetine was significantly lower in the long-term treatment group than other groups, but age, trait anxiety, state anxiety, ratio of major depression, and IIEF score were not different. The reasons of difficulty to reduce paroxetine dose in long-term treatment group and continuing treatment group were deterioration of the physical symptoms (n=10, n=17), or psychological symptoms (n=7, n=7) and anxiety to decrease of dosage (n=1, n=5), respectively. At present, twenty-nine patients in continuing group who tried to reduce paroxetine dose can control by low dose paroxetine. Basically SSRI such as paroxetine should not be used for long term, but some patients are necessary to continue administration of low dose SSRI depend on one's condition.