Abstract
Background and aim : Although there are many reports showing the association with stress and gastrointestinal motility disorders, there is no clinical report that evaluates the gastrointestinal motility disorders in the patients with mental disease who had the functional dyspepsia (FD) in many parameters. In the present study, we evaluated the gastrointestinal motility, the degree of the FD symptom, and the degree of depressive and anxiety in the patients with mental disease who had the FD, and we investigated the characteristics of these data. Subjects and methods : We enrolled twenty-three patients with mental disease who had the FD (7 men and 16 women aged from 16y to 78y, the median age is 38y). All patients were diagnosed as having FD according to the Rome III criteria. We used ultrasonographic method to investigate the gastrointestinal motility and evaluated it in four parameters. To evaluate the degree of the major depressive disorder, anxiety disorder, and FD symptom, we used Hospital Anxiety and Depression scale (HADS) and Gastrointestinal Symptom Rating Scale (GSRS). Results : Five subjects were diagnostic of adjustment disorders, 4 of major depressive disorders, 6 of anxiety and panic disorders, 3 of somatoform disorders and, 1 was bipolar disorder, schizophrenia, intellectual development disorder, obsessive-compulsive disorder and eating disorder each. In the examination of gastrointestinal motility disorders, impaired accommodation reflex of the proximal stomach occurred in 12 patients (52.2), delayed gastric emptying occurred in 9 patients (39.1%), motility disorder in antral contractions occurred in 5 patients (21.7%), and increased duodenogastric reflux occurred in 11 patients (47.8%). However we couldn't find the characteristics of these data. Although we could see a positive correction between the degree of FD symptom and the degree of depression and anxiety disorder or the gastric emptying, we could find no correction between the degree of depression and anxiety disorder and the gastric motility. This suggests that the drugs which improve the accommodation reflex of the proximal stomach or reduce duodenogastric reflux may be effective for the patients with mental disease who had the FD.
