2020 Volume 60 Issue 1 Pages 20-25
Functional dyspepsia (FD) and irritable bowel syndrome (IBS) often overlap each other, and they have similar aspects of pathophysiology. For example, visceral hypersensitivity, intestinal dysmotility, psychologic distress, and onset after acute gastroenteritis. On the psychological aspects, anxiety and depression often coexist with FD and IBS. It has been reported that fibromyalgia and chronic fatigue syndrome also coexist with FD and IBS. In addition, it's important to distinguish organic disease with functional gastrointestinal disorder, so we described differential diagnosis of FD and IBS.
We also examined the comorbidity of FD and IBS in our study of general population (Iwaki Heath Promotion Project). We extracted FD and IBS by the questionnaire of RomeⅢ. We evaluated depressive state by The Center for Epidemiologic Studies Depression Scale (CES-D) and sleep disorder by Pittsburgh Sleep Quality Index (PSQI-J). FD group showed significantly higher score in CES-D than non-FD group. In addition, IBS group showed significantly higher score in CES-D and global score of PSQI-J than non-IBS group. It is suggested that IBS coexisted with depression and sleep disorder. Moreover, IBS group and FD group overlapped with high probability, and there was a strong tendency in the overlapped subjects with depressive state.
