Neuroimaging Evaluation of Pathology Model of a Central Sensitization

Abstract

Although pathology model of a central nerve sensitization can be postulated for eating disorders and psychosomatic disorders, there is no standardized treatment strategy. There is a need to equalize the level of evidence-based treatment. The Ministry of Health, Labour and Welfare (MHLW) policy research project aims to elucidate the pathophysiology of central sensitization and improve patient care in collaboration with other related projects. Specifically, we will implement treatment programs that have been proven to be effective for these diseases and examine the modification of cross-disease central nervous system hyper-responsiveness and desensitization that underlie the improvement in clinical symptoms. Through this investigation, we aim to generate neuroscientific evidence for therapeutic structures and improve patient care with a focus on central nervous system sensitization.

In the first half of this paper, we proposed a central nerve sensitization pathological model as a mechanism of psychosomatic illness. In the second half of the paper, we proposed an attempt to build a brain imaging database of the eating disorder is presented.