Appetite and Orexins

Abstract

Orexin, a neuropeptide produced by neurons in the lateral hypothalamus, has been shown to promote feeding behavior; however, subsequent studies have revealed that it plays an essential role in the regulation of sleep and wakefulness. In addition, orexin is involved in the behavioral preference for more rewarding meals instead of baseline feeding, and functions as a negative regulator of energy metabolism and the prevention of obesity. This study discusses the regulation of feeding, sleep, and energy metabolism by orexin via the central nervous system.