Abstract
We reported a 14-year-old boy revealed poststreptococcal acute glomerulonephritis (PSAGN) with acute renal failure (ARF). He suffered from proteinuria (4.3g/day), hematuria, hypertention (190/110mmHg), edema, oliguria and erysipelas. The laboratory data showed the elevation of BUN (36.7mg/dl), creatinine (2.72mg/dl), and K (5.45mEq/L). The titer of ASO and ASK were elevated, 894 IU/ml and × 20480, respectively. CH50 and C3 serum levels were decreased. The bacterial cultures including blood, throat swab and skin were all negative. ARF due to overhydration, overexercise by judo on the acute phase, was improved by the restriction of salt and water intake, bed rest and treatment with furosemide and penicillin-G. Renal biopsy showed proliferative endocapillary glomerulonephritis on light microscopy, and fine granular pattern of C3 was detected by immunofluorescent studies. Electron microscopic findings showed “humps”, splitting of basement membrane and “apoptosis”. We consider that apoptosis play an important role in recovery process of PSAGN.
