Japanese journal of pediatric nephrology
Online ISSN : 1881-3933
Print ISSN : 0915-2245
ISSN-L : 0915-2245
Original Article
The epidemiology and clinical features of 6 children with male SLE: compared with 17 children with female SLE
Yukihiko KawasakiJunzo SuzukiNobuko SakaiMaki NagaiReiko HoshinoRuriko NozawaSigeo SuzukiHitoshi Suzuki
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Keywords: SLE, male, prognosis
JOURNAL FREE ACCESS

2002 Volume 15 Issue 1 Pages 23-27

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Abstract
  To clarify the pathogenesis of male SLE, we compared clinical manifestation of male SLE with those of female SLE. We enrolled 23 patients who had been diagnosed with SLE. These patients were divided into two groups, 6 patients (Group A) were male and 17 (Group B) were female. The causative agents, clinical features, laboratory data, renal pathological findings, treatment and prognosis were investigated for the two groups. Proteinuria at onset was found in six patients (100%) of group A and in four patients (23.3%) of B (p<0.05). Eighty % of male-SLE patients and 76.5% of female showed type III or more of WHO classification. Patients with cardiac and pulmonary disorder were less seen in group A than in B. Clinical remission occurred in 4 patients (66.7%) of group A and in one patient (5.9%) of B (P<0.05). The relapse rate was higher in group B than in A (P<0.05). These findings suggest that male SLE children may have few complications except renal disorder and were good therapy-response, though male-SLE as same as female SLE have severe pathological findings.
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© 2002 The Japanese Society for Pediatric Nephrology
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