Abstract
To clarify the pathogenesis of male SLE, we compared clinical manifestation of male SLE with those of female SLE. We enrolled 23 patients who had been diagnosed with SLE. These patients were divided into two groups, 6 patients (Group A) were male and 17 (Group B) were female. The causative agents, clinical features, laboratory data, renal pathological findings, treatment and prognosis were investigated for the two groups. Proteinuria at onset was found in six patients (100%) of group A and in four patients (23.3%) of B (p<0.05). Eighty % of male-SLE patients and 76.5% of female showed type III or more of WHO classification. Patients with cardiac and pulmonary disorder were less seen in group A than in B. Clinical remission occurred in 4 patients (66.7%) of group A and in one patient (5.9%) of B (P<0.05). The relapse rate was higher in group B than in A (P<0.05). These findings suggest that male SLE children may have few complications except renal disorder and were good therapy-response, though male-SLE as same as female SLE have severe pathological findings.
