Abstract
A 3 year-old girl was referred to our hospital for chance proteinuria. Proteinuria and microhematuria were positive. Blood examination revealed hypocomplementemia, positive anti-nuclear antibody, and positive anti-double stranded DNA antibody. Anti-streptolysin O was negative. She was diagnosed as lupus nephritis. Since she became febrile after hospitalization, initial renal biopsy was postponed. She was treated with four courses of methylprednisolone pulse therapy. Serum complements raised to normal after the third course of therapy. The renal biopsy performed after the forth pulse therapy demonstrated membranous glomerulonephritis with mild mesangial change (WHO classification of lupus nephritis: class Vb). Her proteinuria disappeared four months after treatment. She is in remission for three years. Low-dose oral prednisolone is still necessary as its reduction causes hypocomplementemia.
