Abstract
We report here three patients with epilepsy who developed urolithiasis during zonisamide(ZNS) treatment. A one-year-old girl had periodic spasms and right single kidney. In addition to ZNS treatment, she received ACTH therapy. The patient developed urolithiasis with resultant acute renal failure and macrohematuria during ACTH therapy. The second patient was 14-year-old girl who had received steroid therapy for mixed connective tissue disease. Four months after the initiation of ZNS therapy, the patient developed urolithiasis. The third patient, who had benzodiazepines treatment for insomnia, suffered with urinary lithiasis during ZNS treatment. The urinalysis of the three patients revealed alkaline urine or hypercalciuria. Although their urinary lithiasis was resolved by discontinuation of ZNS and supportive therapy, routine examination of urine parameters such as pH and sediments, and ultrasonography are thought to be necessary during treatment with ZNS.
