Antiproteinuric effect of the combination therapy with angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in a child with idiopathic membranous nephropathy: case report.

Abstract

We report on a 3 year old girl with idiopathic membranous nephropathy (IMN) who was found by mass screening program for renal disease and achieved complete remission by the combination therapy of angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin receptor blocker (ARB). As IMN in Japanese children was reported to have favorable outcomes, we suggest that these patients with heavy proteinuria may be initially treated with inhibitor of the renin-angiotensin system prior to commencement of steroids.