Abstract
We reported a 14 year old female patient with SLE. We diagnosed ISN/RPS 2003 classification of lupus nephritis class IV-S(A) by renal biopsy. And then we treated her by two intravenous methylprednisolone pulses therapy followed by 20 mg per day oral prednisone, and six monthly pulses of cyclophosphamido therapy. After six month treatments, her laboratory data were improving. But she had some side-effects, moon face and hairiness, by corticosteroid and she was depressed. To our knowledge, we need to do follow-up treatment chronic disease patient at puberty with psychosomatic counseling.