Abstract
The frequency of the obese children are increasing in the recent years, due to the change of lifestyle such as poor exercise, a fat highly-content diet and so on. Recently we encountered three pediatric cases with Obesity-Related Glomerulopathy(ORG). All of these patients showed moderate proteinuria associated with high glomerular hyperfiltration rate, mild hypertension and the enlargement of glomerula size. However, focal glomerular sclerotic change was observed only in one patient. The principal of the therapy for ORG is base on the normalization of GFR by reducing over-weight through adequate diet and exercise, but sometimes it likely to difficult. Therefore ACE-I and ARB are sometimes administered to these patients, and mostly showed effectiveness. Among the obese children with the asymptomatic proteinuria and/or histologically minor glomerular abnormality, ORG could be included.
