2006 Volume 19 Issue 2 Pages 135-140
Two girls with C1q nephropathy were reported. Both patients had moderate proteinuria without nephrotic syndrome. Renal biopsy specimens of both showed predominant mesangial C1q deposition and mesangial electron dense deposits. However, one showed focal segmental sclerosis in light microscopy with minimal deposition of IgG and C3 by immunofluorescence and another showed minor glomerular abnormalities associated with significant immunoglobulins, C3 and C4, so called full house pattern. In the literature light microscopic classification of C1q nephropathy is composed of three categories; minor glomerular abnormalities (MGA), proliferative glomerulonephritis and focal segmental sclerosis. The difference in the category of pathological findings should reflect on the difference of clinical features. The patients with C1q nephropathy must be divided into three groups by light microscopic findings to clarify the pathogenesis and to evaluate the prognosis of C1q nephropathy.
