2007 Volume 20 Issue 1 Pages 55-59
We reported a case of acute tubulointerstitial nephritis (ATIN) with acute renal failure.
The patient was an 8-year-old boy, who was pointed out autism at age of 3 years old and had no previous history of influenza infection. In November 2005, at age of 8 years and 10 months, he was given influenza HA vaccine for the first time. 3 days later, he presented with high grade fever. He was admitted to a hospital with persistent fever of unknown cause. 14 days after vaccination, He progressed to acute renal failure, and then was transferred to our institution. The laboratory tests revealed the following values: white blood cells count 10,900/cmm, C-reactive protein 26.7mg/dl, serum creatinine 5.61mg/dl, urinary beta 2 micro globlin 21,061μg/g creatinine. Continuous hemodiafiltration was performed for seven days, and the renal function recovered. Renal biopsy results were compatible with ATIN. A drug lymphocyte stimulation test (DLST) was positive for influenza HA vaccine. Therefore, influenza HA vaccine was suspected the cause of ATIN. To our knowledge, no previous case of ATIN associated with influenza HA vaccine has been reported.
