A case report of tubulointerstitial nephritis and uveitis (TINU) syndrome found by glucosuria

Abstract

 The patient is a 13 year-old girl who had glucosuria in the course of enuresis. Though she had continuous glucosuria, her blood sugar and HbA1c levels were normal. However, as her serum creatinine and urine β₂MG were high, tubulointerstitial nephritis was suspected. Although she had no eye symptoms, she was diagnosed with bilateral uveitis. A renal biopsy specimen showed typical tubulointerstitial nephritis, and she was also diagnosed with TINU syndrome. Her urinalysis and serum creatinine level improved without specific agents like prednisolone. It is reported that most cases of TINU syndrome recover spontaneously unlike other types of tubulointerstitial nephritis. Therefore, when we encounter renal glucosuria, it is important to consider TINU syndrome even if no eye symptoms exist.