Abstract
We measured serum concentration of mizoribine in 16 children with chronic renal deseases. Mizoribine was administered orally at a dose of 5mg/kg (range, 4.3-5.9 mg/kg) as a single daily dose before breakfast. The relationship between pharmacokinetic parameters of mizoribine and clinical parameters, such as sex, age, and the predonisolone dose was examined. Tmax was 1.67±0.50 hours, Cmax was 2.70±1.13 μg/ml, and AUCinf was 13.80±5.58 μg·h/ml. There was a positive correlation between age and AUCinf (r0.64, P=0.0074). There was a negative correlation between PSL dosage and Cmax (r-0.55, p=0.0287) and AUCinf (r-0.51, p=0.0421). It is necessary to investigate factors which has an influence on pharmacokinetics of mizoribine.
