Examination of human Na+/nucleoside cotransporter (hCNT2) in mizoribine absorption

Abstract

 Little is known about the mechanisms of mizoribine (MZR) absorption. We evaluated the role of the human Na+/nucleoside cotransporter (hCNT2) transportation system in MZR absorption.
 It was proven to the absorption of MZR that the carrier mechanism in the enteric canal by hCNT2 was taking part. Our conclusive finding indicated that the consideration of food style could be necessary for MZR absorption rate, because MZR absorption can be compete from inosinic acid. Significant correlation between hCNT2 polymorphism and the rate of MZR absorption was not demonstrated in this study, however more large scale study should be required in future study.