2008 Volume 21 Issue 2 Pages 134-137
It is generally understood that cyclosporin A (CyA) can be used safety without adverse effects including renal toxicity when keeping adequate plasma drug concentration for about two years. We encountered four boys with frequent relapsing nephrotic syndrome exhibited glomerular sclerosis despite optimal use of CyA therapy within two years. CyA arteriopathy representing hyalinosis of vessel walls was concomitantly observed with relatively high incidence. We noticed that this phenomenon is closely related to the frequency of premature glomerulus that exists after birth. Vasocontruction of glomerular arteries by CyA could be affect the blood supply into glomerulus. Lack of several glomerular maturation factors in blood could be lead to maturation failure of glomerulus. CyA therapy may inhibit glomerular maturation after birth. Caution is required when use CyA for younger children presumably having premature glomerulus exist even after birth.
