2009 Volume 22 Issue 1 Pages 35-40
We report two cases of idiopathic nephrotic syndrome following rh-GH treatment. Two cases were introduced to rh-GH therapy due to Turner syndrome and GH deficiency disease. Two cases present nephrotic syndrome 2 weeks and 3 years after initiation of GH treatment, respectively. Both two cases showed favorable clinical course with conventional corticosteroid treatment for nephrotic syndrome. Until now we are not recognized relapse with nephrotic syndrome in two cases. To date there is few clinical reports concerning nephrotic syndrome and rh-GH treatment, while it is suggested that GH could change a size selective filtration barrier formed by fenestrated endothelium, glomerular podocytes, and glomerular basement membrane, leading to the appearance of proteinuria. Including above mentioned results, it is clinically important to follow up these children and investigate the relationship between rh-GH and proteinuria.
